Cancer will affect a growing number of patients and remains one of the most feared diagnoses for patients. Integrative oncology has been defined as a patient-centered, evidence-informed field of cancer care that utilizes techniques such as mind body therapy, activities such as acupuncture and therapies such as diet and dietary supplements, alongside conventional cancer treatments to optimize health, quality of life, and clinical outcomes of patients during and after cancer treatment. Evidence will be presented that supports the effectiveness of integrative oncology for this purpose. Utilization of Integrative Oncology services and/or its component therapies is widespread among cancer patients. During radiation therapy, use of complementary therapies and dietary supplements may be as high as 80% with use during care for certain high risk cancers exceeding 90%. Patients hospitalized for cancer treatment report significant use (73% in the previous month). Even during Phase I clinical trials, a third of cancer patients used supplements. In response to wide-spread demand by patients as well as evidence of effectiveness, many National Cancer Institute Centers of Excellence have added Integrative Oncology (IO) services to their programs. In fact, a recent study has suggested that in centers where IO has been added, the outcomes of breast cancer patients, including increased 5-year survival is improved. Of the wide variety of therapies utilized by patients, a number have been studied in randomized controlled trials and will be discussed in this presentation. Modalities such as acupuncture and massage therapy have shown benefit for pain. Mind-body therapy has relieved anxiety as has psychosocial support. Dietary supplements have been tested and shown benefit for treatment-related co-morbidities. Cancer related fatigue and sleep quality have been improved with herbal therapy. Chemotherapy related conditions, such as nausea, mucositis, neuropathy and treatment related diarrhea have been mitigated by use of a variety of supplements. Safety of integrative interventions is naturally a concern for oncologists and their patients. Potential situations of risk will be elaborated and the evidence support safe use will be addressed. Herb-drug interactions is often of particular concern for physicians and information on how to assess this risk will be given.